UK HSP Support Group 2021: HSP Genes in the UK and building a registry

UK HSP Support Group 2021: HSP Genes in the UK and building a registry

This video was recorded on 17th July 2021.
Professor Henry Houlden talks about the different HSP genes, the diagnosis path for HSP, and building a registry or bioresource for future biomarkers and trials.

01:33 – All HSP is caused by a gene mutation
02:30 – HSP may not be the cause of all ‘problems’
02:42 – videos of people with HSP – walking
04:06 – videos of people with HSP – tremors and clonus
05:12 – what is HSP?
06:50 – ‘Pure’ HSP
07:25 – ‘Complex’ HSP
08:08 – HSP inheritance
09:00 – finding the HSP genes
10:49 – dominant HSP is most common in the UK, SPG4 then SPG3A
13:26 – recessive HSP – SPG7 then SPG11 most common. 1-2% of population carry SPG7
15:59 – making a diagnosis of HSP
16:53 – the clinic in London
18:30 – treatment options for HSP
22:02 – HSP onset age
22:47 – discovery of HSP genes over time
24:05 – how HSP presents in clinic, typically
25:43 – videos of people with HSP – eyes and balance
27:37 – video of walking with SPG11
28:51 – how do we get better drugs for HSP?
31:12 – what are drug companies looking for?
34:09 – example: MSA
36:56 – UK registry for people with HSP

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